BDBM50628905 CHEMBL5411897

SMILES OCC(O)CNc1nc(Nc2cccc(c2)C(F)(F)F)nc(Nc2cccc(n2)C(F)(F)F)n1

InChI Key InChIKey=QWDAGHQOEYXWTO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50628905   

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50628905(CHEMBL5411897)
Affinity DataIC50: 160nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) using alpha-ketoglutarate as substrate incubated for 16 hrs in the presence of NADPH by absorbance b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50628905(CHEMBL5411897)
Affinity DataIC50: 298nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) using alpha-ketoglutarate as substrate incubated for 1 hrs in the presence of NADPH by absorbance ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50628905(CHEMBL5411897)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of wildtype IDH2 (unknown origin) using alpha-ketoglutarate as substrate incubated for 1 hrs in the presence of NADPH by absorbance based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed