BDBM50628858 CHEMBL5401472

SMILES C[C@H]1CCCN1c1cc(nnc1N)-c1ccccc1O

InChI Key InChIKey=CMJYPZQQLQOFCI-UHFFFAOYSA-N

Data  1 IC50  9 Kd  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50628858   

LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataKd:  42nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRetinoic acid receptor alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at RARalpha in GeneBLAzer RARalpha-UAS-bla HEK 293T cells preincubated with compound for 16 to 24 hrs followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at LXRbeta in GeneBLAzer LXRbeta-UAS-bla HEK 293T cells preincubated with compound for 16 to 24 hrs followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at LXRalpha in GeneBLAzer LXRalpha-UAS-bla HEK 293T cells preincubated with compound for 16 to 24 hrs followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to RXR alpha (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataEC50:  6.00E+3nMAssay Description:Binding affinity to LXRbeta (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to LXR alpha (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataEC50:  850nMAssay Description:Agonist activity at PXR (unknown origin) by cellular reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataIC50: 600nMAssay Description:Binding affinity to PXR (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataKd:  22nMAssay Description:Binding affinity to PBRM1 bromodomain 5 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataKd:  50nMAssay Description:Binding affinity to PBRM1 bromodomain 5 (unknown origin) assessed as dissociation constant by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataKd:  250nMAssay Description:Binding affinity to PBRM1 bromodomain 4 (unknown origin) assessed as dissociation constant by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataKd:  62nMAssay Description:Binding affinity to PBRM1 bromodomain 3 (unknown origin) assessed as dissociation constant by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataKd:  30nMAssay Description:Binding affinity to PBRM1 bromodomain 2 (unknown origin) assessed as dissociation constant by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTranscription activator BRG1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataKd:  16nMAssay Description:Binding affinity to SMARCA4 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataKd:  20nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataKd:  15nMAssay Description:Binding affinity to PBRM1 bromodomain 2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed