BDBM50628739 CHEMBL5423601

SMILES Cc1c2cc(cc1C(=O)Nc3cc(cc(c3)C4CC4)CN5CCN(CC5)C)OCCCCCCCNC(=O)c6ccc7ncc(n7n6)C#C2

InChI Key InChIKey=YOBIWCLAYQWPPW-UHFFFAOYSA-N

Data  19 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50628739   

TargetEphrin type-A receptor 7(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of EphA7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 59nMAssay Description:Inhibition of FLT4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 67nMAssay Description:Inhibition of P70S6K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 26nMAssay Description:Inhibition of Mer (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 74nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase HCK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 253nMAssay Description:Inhibition of Hck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 14(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 155nMAssay Description:Inhibition of CDK14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetAngiopoietin-1 receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 66nMAssay Description:Inhibition of Tie2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 12nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of N-terminal hexa his tagged TRKA (485 to 795 residues) (unknown origin) expressed in baculovirus expression system Sf9 cells using Ser/T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 5(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 23nMAssay Description:Inhibition of EphA5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 13nMAssay Description:Inhibition of EphA2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 24nMAssay Description:Inhibition of DDR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 13nMAssay Description:Inhibition of Musk (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) expressed in baculovirus expression system Sf9 cells using Ser/Thr 06 as peptide substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) expressed in baculovirus expression system Sf9 cells using Ser/Thr 06 as peptide substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNT-3 growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of TRKC (unknown origin) using Ser/Thr 06 as peptide substrate incubated for 1 hr in presence of ATP by FRET based Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed