BDBM50628242 CHEMBL5396270

SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCCNC(=N)NC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)cc(c2c1)C(F)(F)F

InChI Key InChIKey=INUCDYAEQINYDK-UHFFFAOYSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50628242   

TargetProtein arginine N-methyltransferase 9(Homo sapiens)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628242(CHEMBL5396270)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant PRMT9 using biotinylated SF3B2(500 to 519 residues) as substrate and SAM as cosubstrate pre-incubated with compound f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628242(CHEMBL5396270)
Affinity DataIC50: 4.89E+4nMAssay Description:Inhibition of N-terminal/C-terminal GST-tagged human recombinant full-length PRMT1 (2 to 371 residues) using histone H4 as substrate and 3H-SAM as co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628242(CHEMBL5396270)
Affinity DataIC50: 1.49E+4nMAssay Description:Inhibition of N-terminal/C-terminal His-tagged human recombinant full-length PRMT3 (2 to 531 residues) using histone H4 as substrate and 3H-SAM as co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628242(CHEMBL5396270)
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of N-terminal/C-terminal GST-tagged human recombinant full-length PRMT4 (2 to 608 residues) using histone H3.3 as substrate and 3H-SAM as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628242(CHEMBL5396270)
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of N-terminal/C-terminal human recombinant full-length FLAG-tagged PRMT5 (2 to 637 residues)/C-terminal human His-tagged MEP50 (2 to 342 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628242(CHEMBL5396270)
Affinity DataIC50: 4.97E+4nMAssay Description:Inhibition of N-terminal/C-terminal GST-tagged human recombinant full-length PRMT6 (2 to 375 residues) using histone GST-GAR as substrate and 3H-SAM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628242(CHEMBL5396270)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of N-terminal/C-terminal His-tagged human recombinant full-length PRMT7 (2 to 692 residues) using histone GST-GAR as substrate and 3H-SAM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628242(CHEMBL5396270)
Affinity DataIC50: 1.97E+3nMAssay Description:Inhibition of N-terminal/C-terminal His-tagged human recombinant full-length PRMT8 (61 to 394 residues) using histone H4 as substrate and 3H-SAM as c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 9(Homo sapiens)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628242(CHEMBL5396270)
Affinity DataKd:  188nMAssay Description:Binding affinity to N-terminal/C-terminal FLAG/6His-tagged human PRMT9 (2 to 845 residues) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed