BDBM50628109 CHEMBL5437552

SMILES [2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(cn2)C(C)(C)O)cc1Nc1nccc(-c2ncc(F)cn2)c1OC

InChI Key InChIKey=RVSZIUKIBYCERM-HPRDVNIFSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50628109   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50628109(CHEMBL5437552)
Affinity DataIC50: 0.100nMAssay Description:Displacement of fluorescein-labeled kinase tracer from His-TVMV-TYK2 JH2 (575 to 869 residues) (unknown origin) measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50628109(CHEMBL5437552)
Affinity DataIC50: 41nMAssay Description:Inhibition of TYK2 JH2 domain in human whole blood assessed as reduction in IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50628109(CHEMBL5437552)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of JAK1 (unknown origin) assessed as reduction in IL-2 induced activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50628109(CHEMBL5437552)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of JAK3 (unknown origin) assessed as reduction in IL-2 induced activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50628109(CHEMBL5437552)
Affinity DataEC50: >5.00E+4nMAssay Description:Activity at PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50628109(CHEMBL5437552)
Affinity DataEC50: >2.00E+3nMAssay Description:Activity at PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50628109(CHEMBL5437552)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of UGT1A1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed