BDBM50627973 CHEMBL5402315

SMILES CN1CCN(CC1=O)C12CCC(Cn3nc(C)c4CN(CCc34)c3cc(C)nc4n(C)ncc34)(CC1)CC2

InChI Key InChIKey=CQSXCOJVRDNCPQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50627973   

TargetToll-like receptor 7(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627973(CHEMBL5402315)
Affinity DataIC50: 56nMAssay Description:Antagonist activity at TLR7 in human PBMC cells assessed as reduction in IFN alpha measured after 20 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627973(CHEMBL5402315)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at TLR8 in human PBMC cells expressed in Drosophila S2 expression system assessed as reduction in IL-6 level measured after 20 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetToll-like receptor 9(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627973(CHEMBL5402315)
Affinity DataIC50: 7.30E+3nMAssay Description:Antagonist activity at TLR9 in human PBMC cells assessed as reduction in IFN alpha measured after 20 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed