BDBM50627970 CHEMBL5405310

SMILES CN[C@@H](C)C(=O)NC12CCC(Cn3nc(C)c4CN(CCc34)c3cc(C)nc4n(C)ncc34)(CC1)CC2

InChI Key InChIKey=CQISSFUPPYBAEU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50627970   

TargetToll-like receptor 7(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627970(CHEMBL5405310)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at TLR7 in human PBMC cells assessed as reduction in IFN alpha measured after 20 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627970(CHEMBL5405310)
Affinity DataIC50: 190nMAssay Description:Antagonist activity at TLR8 in human PBMC cells expressed in Drosophila S2 expression system assessed as reduction in IL-6 level measured after 20 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetToll-like receptor 9(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627970(CHEMBL5405310)
Affinity DataIC50: 700nMAssay Description:Antagonist activity at TLR9 in human PBMC cells assessed as reduction in IFN alpha measured after 20 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed