BDBM50627874 CHEMBL4289149

SMILES NC(=O)c1cnc2c(NC3CC3)cc(Nc3cc(cc(c3)C(F)(F)F)C#N)nn12

InChI Key InChIKey=LZDFDVIPCRRLMW-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50627874   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627874(CHEMBL4289149)
Affinity DataIC50: 480nMAssay Description:Inhibition of N-terminal His-tagged human TYK2 JH2 domain incubated for 30 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50627874(CHEMBL4289149)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant IKKbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627874(CHEMBL4289149)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627874(CHEMBL4289149)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of TYK2 JH2 in human KIT225 cells assessed as reduction of IFNalpha induced STAT1 phosphorylation by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627874(CHEMBL4289149)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant JAK2 JH1 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627874(CHEMBL4289149)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627874(CHEMBL4289149)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant JAK1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed