BDBM50627813 CHEMBL5416344

SMILES OC(=O)CCNC(=S)NCCCNc1nc(Nc2ccccc2Cl)ncc1C(=O)N1CC[C@@H](C1)c1ccccc1

InChI Key InChIKey=YVUGRSDTNXBWNT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50627813   

LigandPNGBDBM50627813(CHEMBL5416344)
Affinity DataIC50: 310nMAssay Description:Inhibition of human SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50627813(CHEMBL5416344)
Affinity DataIC50: 1.13E+5nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) using Ac-Arg-Leu-lle-Lys (Ac)-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50627813(CHEMBL5416344)
Affinity DataIC50: 3.96E+4nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using Ac-Glu-Thr-Asp-Lys (Dec)-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50627813(CHEMBL5416344)
Affinity DataIC50: 1.50E+6nMAssay Description:Inhibition of recombinant SIRT3 (unknown origin) using Ac-Arg-Leu-lle-Lys (Ac)-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed