BDBM50627464 CHEMBL5426285

SMILES CC(C)C[C@H](COC)NC1=N/C(=C\c2ccc3c(c2)scn3)/C(=O)N1

InChI Key InChIKey=CHQYAWLKOUOTQO-UHFFFAOYSA-N

Data  53 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 56 hits for monomerid = 50627464   

TargetDual specificity protein kinase CLK1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 16nMAssay Description:Inhibition of human CLK1 using myelin basic protein as substrate measured after 70 mins by ADP-GloTM luminescence proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 93nMAssay Description:Inhibition of human DYRK2 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 310nMAssay Description:Inhibition of human DYRK3 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of human HASPIN assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of human HIPK1 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 317nMAssay Description:Inhibition of human HIPK2 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 3(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 634nMAssay Description:Inhibition of human HIPK3 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 620nMAssay Description:Inhibition of human HIPK4 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetcGMP-dependent protein kinase 2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 118nMAssay Description:Inhibition of human PRKG2 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTranscription initiation factor TFIID subunit 1-like(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human TAF1L assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase TAO1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 596nMAssay Description:Inhibition of human TAO1 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase TAO2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TAO2 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase TAO3(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human TAO3 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTribbles homolog 2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 12nMAssay Description:Inhibition of human TRB2 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 6nMAssay Description:Inhibition of human DYRK1B assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human DYRK1A using DYRKtide peptide as substrate measured after 70 mins by ADP-GloTM luminescence proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 8nMAssay Description:Inhibition of human DYRK1B using DYRKtide peptide as substrate measured after 70 mins by ADP-GloTM luminescence proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataKd:  0.276nMAssay Description:Binding affinity to human DYRK1A assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataKd:  0.388nMAssay Description:Binding affinity to human CLK1 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataKd:  603nMAssay Description:Binding affinity to human GSK3beta assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 3nMAssay Description:Inhibition of human DYRK1A using RBERCHKtide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 8nMAssay Description:Inhibition of human DYRK1B using RBERCHKtide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 273nMAssay Description:Inhibition of human DYRK2 using RBERIRStide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of human DYRK3 using RBERIRStide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 248nMAssay Description:Inhibition of human DYRK4 using RBERCHKtide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of N-terminal GST/His6-fused human full length GSK-3-beta (1 to 420 residues) expressed in Sf9 cells using RBERCHKtide and [gamma33P]ATP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCasein kinase I isoform epsilon(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CK1 epsilon using casein and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST/His6-fused human full length CDK5 (1 to 292 residues)/N-terminal His6-fused human p25 (104 to 307 residues) coexpressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 388nMAssay Description:Inhibition of human recombinant DYRK4 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 38nMAssay Description:Inhibition of human CLK2 using GSK3(14-27) peptide and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 12nMAssay Description:Inhibition of human CLK1 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation counting based ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK4(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 5nMAssay Description:Inhibition of human CLK4 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation counting based ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK3(Homo sapiens)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 208nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human DYRK1A assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation counting based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human DYRK1B assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation counting based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CDK5 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CK1 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant CLK2 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 6nMAssay Description:Inhibition of human CLK4 using MBP and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK3(Homo sapiens)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 232nMAssay Description:Inhibition of human recombinant CLK3 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 202nMAssay Description:Inhibition of human recombinant DYRK2 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human recombinant DYRK3 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 9nMAssay Description:Inhibition of N-terminal GST/His6-fused human full length CLK1 (1 to 484 residues) expressed in Sf9 cells assessed as inhibition of autophosphorylati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of human recombinant GSK3 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetAP2-associated protein kinase 1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 106nMAssay Description:Inhibition of human AAK1 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase-like 1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDKL1 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase-like 2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDKL2 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase-like 3(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human CDKL3 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase-like 4(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CDKL4 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase-like 5(Homo sapiens)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of human CDKL5 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
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