BDBM50626657 CHEMBL5405436

SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/CNc3ccc(F)cc23)c1C

InChI Key InChIKey=JHWZPTAZWZKCEQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50626657   

TargetVascular endothelial growth factor receptor 2(Human)
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM50626657(CHEMBL5405436)
Affinity DataIC50: 100nMAssay Description:Inhibition of human VEGFR2 using MEK1 as substrate incubated for 40 mins by gamma33P-ATP based scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM50626657(CHEMBL5405436)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human PDGFRbeta using MEK1 as substrate incubated for 40 mins by gamma33P-ATP based scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM50626657(CHEMBL5405436)
Affinity DataIC50: 77nMAssay Description:Inhibition of human c-Kit using MEK1 as substrate incubated for 40 mins by gamma33P-ATP based scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM50626657(CHEMBL5405436)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human FGFR1 using MEK1 as substrate incubated for 40 mins by gamma33P-ATP based scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM50626657(CHEMBL5405436)
Affinity DataIC50: 19nMAssay Description:Inhibition of human FLT3 using MEK1 as substrate incubated for 40 mins by gamma33P-ATP based scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM50626657(CHEMBL5405436)
Affinity DataIC50: 25nMAssay Description:Inhibition of human CSF1R using MEK1 as substrate incubated for 40 mins by gamma33P-ATP based scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM50626657(CHEMBL5405436)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human EGFR using MEK1 as substrate incubated for 40 mins by gamma33P-ATP based scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed