BDBM50625901 CHEMBL5427191::US20250059185, Example 29

SMILES C[C@@H]1N(CCc2c1nn(C)c2-c1cc(F)cc(F)c1)C(=O)c1cc(F)cc(-c2ccc(=O)[nH]c2)c1Cl

InChI Key InChIKey=BVYLJBZGLXBQBT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50625901   

TargetMonoglyceride lipase(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50625901(CHEMBL5427191 | US20250059185, Example 29)
Affinity DataIC50: 1nMAssay Description:Inhibition of MAGL (unknown origin) using 2-arachidonoylglycerol as substrate preincubated with compound for 15 mins followed by substrate addition a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50625901(CHEMBL5427191 | US20250059185, Example 29)
Affinity DataIC50: 1nMAssay Description:MAGL inhibitory activity by determining the enzymatic activity by following the hydrolysis of the natural substrate 2-arachidonoylglycerol (2-AG) res...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/19/2025
Entry Details
Go to US Patent