BDBM50625899 CHEMBL5407077::US20250059185, Example 7

SMILES COc1cccc(C(=O)N2CCc3c(nn(C)c3-c3cc(Cl)cc(c3)C3(CC3)NS(C)(=O)=O)[C@@H]2C)c1Cl

InChI Key InChIKey=MBAPNTNQQUVUQS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50625899   

TargetMonoglyceride lipase(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50625899(CHEMBL5407077 | US20250059185, Example 7)
Affinity DataIC50: 17nMAssay Description:Inhibition of MAGL (unknown origin) using 2-arachidonoylglycerol as substrate preincubated with compound for 15 mins followed by substrate addition a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50625899(CHEMBL5407077 | US20250059185, Example 7)
Affinity DataIC50: 17nMAssay Description:MAGL inhibitory activity by determining the enzymatic activity by following the hydrolysis of the natural substrate 2-arachidonoylglycerol (2-AG) res...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/19/2025
Entry Details
Go to US Patent