BDBM50625418 CHEMBL5395998

SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(-c3cn(CCCN4CCOCC4)nn3)n2n1

InChI Key InChIKey=SLVDFWRJWQJSRW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50625418   

LigandPNGBDBM50625418(CHEMBL5395998)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by Kinase-Glo plus luminescent assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50625418(CHEMBL5395998)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50625418(CHEMBL5395998)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50625418(CHEMBL5395998)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50625418(CHEMBL5395998)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of mTOR (unknown origin) using ULight-4E-BP1 (Thr37/46) as peptide substrate incubated for 30 mins in presence of ATP by LANCE Ultra assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed