BDBM50623628 CHEMBL5407194

SMILES CC(C)(c1cc(NC(=O)Nc2ccc(cc2)-c2cc([nH]n2)-c2ccc(OCCN3CCOCC3)cc2)no1)C(F)(F)F

InChI Key InChIKey=KVGTWUGUDPNRGC-UHFFFAOYSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50623628   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50623628(CHEMBL5407194)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to RET (unknown origin) assessed as dissociation constant in presence of ATP by FRET based Z'-Lyte assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50623628(CHEMBL5407194)
Affinity DataIC50: 21nMAssay Description:Inhibition of RET (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50623628(CHEMBL5407194)
Affinity DataIC50: 18nMAssay Description:Inhibition of RET V804M mutant (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50623628(CHEMBL5407194)
Affinity DataIC50: 108nMAssay Description:Inhibition of CSF1R (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50623628(CHEMBL5407194)
Affinity DataIC50: 67nMAssay Description:Inhibition of DDR1 (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50623628(CHEMBL5407194)
Affinity DataIC50: 45nMAssay Description:Inhibition of KIT (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50623628(CHEMBL5407194)
Affinity DataIC50: 16nMAssay Description:Inhibition of PDGFRB (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50623628(CHEMBL5407194)
Affinity DataIC50: 380nMAssay Description:Inhibition of VEGFR2 (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50623628(CHEMBL5407194)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed