BDBM50623332 CHEMBL5423593

SMILES C\N=c1/nc(-c2ccc(F)cc2)n(s1)-c1ccccc1

InChI Key InChIKey=YBCTXELRRVXUMP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50623332   

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623332(CHEMBL5423593)
Affinity DataIC50: 118nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623332(CHEMBL5423593)
Affinity DataIC50: 448nMAssay Description:Inhibition of SARS-CoV-2 PLpro using RLRGG-AMC substrate preincubated for 30 mins followed by substrate addition measured for 5 mins by fluorescence ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetChymotrypsinogen B2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623332(CHEMBL5423593)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of chymotrypsin (unknown origin) using N-succinyl-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623332(CHEMBL5423593)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Cathepsin B using Z-RR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 10 mins by FRET assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623332(CHEMBL5423593)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Cathepsin L using Z-VVR-AMC as substrate measured for 10 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed