BDBM50622916 CHEMBL5305160

SMILES CC1(c2cnc(nc2N(C1=O)[C@H]3CCc4c3cccc4O)Nc5cccc(c5)CN6CCCC6)C

InChI Key InChIKey=OFIFLUFVENTCNZ-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50622916   

TargetSerine/threonine-protein kinase SIK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 110nMAssay Description:Inhibition of GST fused recombinant SIK1 (unknown origin) expressed in HEK293 cells ALNRTSSDSALHRRR as substrate incubated for 1 hr in presence of AT...More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 12nMAssay Description:Inhibition of GST fused recombinant SIK2 (unknown origin) expressed in HEK293 cells ALNRTSSDSALHRRR as substrate incubated for 1 hr in presence of AT...More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 43nMAssay Description:Inhibition of GST fused recombinant SIK3 (unknown origin) expressed in HEK293 cells ALNRTSSDSALHRRR as substrate incubated for 1 hr in presence of AT...More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase MARK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 2nMAssay Description:Inhibition of MARK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 3nMAssay Description:Inhibition of MARK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 2nMAssay Description:Inhibition of MARK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 2nMAssay Description:Inhibition of MARK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 3nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 10nMAssay Description:Inhibition of AMPKalpha1/2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 29nMAssay Description:Inhibition of MELK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMaternal embryonic leucine zipper kinase(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 120nMAssay Description:Inhibition of MELK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase SIK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 110nMAssay Description:Inhibition of SIK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 12nMAssay Description:Inhibition of SIK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 43nMAssay Description:Inhibition of SIK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed