BDBM50622721 CHEMBL5406796

SMILES COC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H](N1C(=O)CCl)c1ccc(cc1)C(=O)N1CCN(CCCCCCCCCCCCCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(cc2)-c2scnc2C)C(C)(C)C)CC1

InChI Key InChIKey=XQGWKMPLXWKSTO-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50622721   

TargetPhospholipid hydroperoxide glutathione peroxidase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50622721(CHEMBL5406796)
Affinity DataEC50:  23nMAssay Description:Induction of GPX4 degradation in human HT-1080 cells measured for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPhospholipid hydroperoxide glutathione peroxidase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50622721(CHEMBL5406796)
Affinity DataEC50:  136nMAssay Description:Induction of GPX4 degradation in human Calu-1 cells measured for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPhospholipid hydroperoxide glutathione peroxidase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50622721(CHEMBL5406796)
Affinity DataEC50:  43nMAssay Description:Induction of GPX4 degradation in human NCI-H1650 cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPhospholipid hydroperoxide glutathione peroxidase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50622721(CHEMBL5406796)
Affinity DataEC50:  26nMAssay Description:Induction of GPX4 degradation in human Gefitinib-resistant H1650 cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed