BDBM50621262 CHEMBL5421982

SMILES COC1CCN(CC1)c1cc(nc2n(nc(C3CCC3)c12)-c1ccc(F)cc1)C(=O)NS(=O)(=O)N(C)C

InChI Key InChIKey=VQHIABNUZGYFSY-UHFFFAOYSA-N

Data  8 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50621262   

LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataEC50:  695nMAssay Description:Corrector activity at HRP-tagged CFTR F508del mutant in human CFBE41o- cells assessed as rescue trafficking by measuring increase in membrane express...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataEC50:  273nMAssay Description:Corrector activity at HRP-tagged CFTR F508del mutant in human CFBE41o- cells assessed as rescue trafficking by measuring increase in membrane express...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataEC50:  47nMAssay Description:Corrector activity at CFTR F508del mutant in forskolin-stimulated human bronchial epithelial cells derived from primary CF assessed as increase in me...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataEC50:  71nMAssay Description:Corrector activity at CFTR F508del mutant in forskolin-stimulated human bronchial epithelial cells derived from primary CF assessed as GLPG1837-media...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S- mephenytoin as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human H1 receptorMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
LigandPNGBDBM50621262(CHEMBL5421982)
Affinity DataIC50: 360nMAssay Description:Inhibition of human Sigma receptorMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed