BDBM50620646 CHEMBL5422760

SMILES [H][C@]12CCCCN1CCC[C@H]2CSCCCNc1ccc(C)c2sc3ccccc3c(=O)c12

InChI Key InChIKey=RTSVPQGEMHVGDV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50620646   

TargetMicrotubule-associated protein tau(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50620646(CHEMBL5422760)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of tau (unknown origin) aggregation expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50620646(CHEMBL5422760)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of amyloid beta 40 peptide (unknown origin) aggregation incubated for 2 hr by ThT fluorescence based spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Electric eel)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50620646(CHEMBL5422760)
Affinity DataIC50: 180nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by DTNB reagent b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50620646(CHEMBL5422760)
Affinity DataIC50: 7.84E+3nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by DTNB reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCholinesterase(Horse)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50620646(CHEMBL5422760)
Affinity DataIC50: 88nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by DTNB reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCholinesterase(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50620646(CHEMBL5422760)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant BChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by DTNB reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed