BDBM50620626 CHEMBL5399538

SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3C[C@@H](F)C[C@@H]3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1

InChI Key InChIKey=AUMBLLOUWYMBSQ-UHFFFAOYSA-N

Data  1 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50620626   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50620626(CHEMBL5399538)
Affinity DataIC50: 2nMAssay Description:Inhibition of human PD-1/PD-L1 interaction assessed as induction of PD-L1 dimerization incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50620626(CHEMBL5399538)
Affinity DataKd:  8nMAssay Description:Binding affinity to human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University Medical Center Groningen

Curated by ChEMBL
LigandPNGBDBM50620626(CHEMBL5399538)
Affinity DataEC50:  880nMAssay Description:Inhibition of PD-1/PD-L1 interaction in human Jurkat T cells cocultured with artificial antigen presenting cells assessed as increase in TCR-mediated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed