BDBM50620522 CHEMBL5410401

SMILES C[C@H]1COCCN1c1cc(N2CCOC[C@H]2C)c2nc(sc2n1)-c1cscn1

InChI Key InChIKey=OQYUEKNIOFLPLT-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50620522   

TargetSerine/threonine-protein kinase mTOR(Mouse)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50620522(CHEMBL5410401)
Affinity DataIC50: 56nMAssay Description:Inhibition of mTOR in TSC1 knockout mouse MEF cells assessed as reduction in phosphorylated S6 level at serine 240/244 residues incubated for 2 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50620522(CHEMBL5410401)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50620522(CHEMBL5410401)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50620522(CHEMBL5410401)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50620522(CHEMBL5410401)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50620522(CHEMBL5410401)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50620522(CHEMBL5410401)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50620522(CHEMBL5410401)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50620522(CHEMBL5410401)
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of ATR (unknown origin)-driven CHK1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50620522(CHEMBL5410401)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed