BDBM50620360 CHEMBL5430060::US20240425496, Compound E8

SMILES Cc1cc(Nc2ncc(C)c(n2)N2CC(CC#N)(C2)N2CCCC2)sn1

InChI Key InChIKey=OPRMTHPWLRWOPL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50620360   

TargetTyrosine-protein kinase JAK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620360(CHEMBL5430060 | US20240425496, Compound E8)
Affinity DataIC50: 7nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620360(CHEMBL5430060 | US20240425496, Compound E8)
Affinity DataIC50: 192nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620360(CHEMBL5430060 | US20240425496, Compound E8)
Affinity DataIC50: 22nMAssay Description:Inhibition of AURKB (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620360(CHEMBL5430060 | US20240425496, Compound E8)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of KDR (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620360(CHEMBL5430060 | US20240425496, Compound E8)
Affinity DataIC50: 3.57E+3nMAssay Description:Inhibition of ABL1 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620360(CHEMBL5430060 | US20240425496, Compound E8)
Affinity DataIC50: 6.98E+3nMAssay Description:Inhibition of GSK3B (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50620360(CHEMBL5430060 | US20240425496, Compound E8)
Affinity DataIC50: 10nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620360(CHEMBL5430060 | US20240425496, Compound E8)
Affinity DataIC50: 10nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent