BDBM50620352 CHEMBL5410239

SMILES Cc1cc(Nc2ncc(C)c(n2)N2CC3CCCC(C2)N3CC#N)sn1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50620352   

TargetTyrosine-protein kinase JAK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620352(CHEMBL5410239)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620352(CHEMBL5410239)
Affinity DataIC50: 771nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620352(CHEMBL5410239)
Affinity DataIC50: 364nMAssay Description:Inhibition of AURKB (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620352(CHEMBL5410239)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of KDR (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620352(CHEMBL5410239)
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of ABL1 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620352(CHEMBL5410239)
Affinity DataIC50: 3.24E+3nMAssay Description:Inhibition of GSK3B (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed