BDBM50620348 CHEMBL5429675

SMILES CC1CN(CCN1CC#N)c1nc(Nc2cc(C)ns2)ncc1C

InChI Key InChIKey=IYCVFSSCAPZAJP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50620348   

TargetTyrosine-protein kinase JAK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620348(CHEMBL5429675)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620348(CHEMBL5429675)
Affinity DataIC50: 152nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620348(CHEMBL5429675)
Affinity DataIC50: 3nMAssay Description:Inhibition of AURKB (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620348(CHEMBL5429675)
Affinity DataIC50: 55nMAssay Description:Inhibition of KDR (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620348(CHEMBL5429675)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of ABL1 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620348(CHEMBL5429675)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of GSK3B (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed