BDBM50620345 CHEMBL5396135::US20240425496, Compound E5

SMILES Cc1cc(sn1)Nc2ncc(c(n2)N3CC(C3)(CC#N)N4CCN(CC4)C)C

InChI Key InChIKey=VGBYAYCYPVFDTM-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50620345   

TargetTyrosine-protein kinase JAK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK3(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 70nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of TYK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 162nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 441nMAssay Description:Inhibition of AURKB (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of KDR (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of ABL1 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GSK3B (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 7nMAssay Description:Inhibition of JAK1 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 10nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620345(CHEMBL5396135 | US20240425496, Compound E5)
Affinity DataIC50: 10nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)