BDBM50620336 CHEMBL5423566

SMILES Cc1cc(Nc2ncc(Cl)c(n2)-c2cnn(CCC#N)c2)sn1

InChI Key InChIKey=VHTVGRLZQWFMBU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50620336   

TargetTyrosine-protein kinase JAK3(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620336(CHEMBL5423566)
Affinity DataIC50: 7nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620336(CHEMBL5423566)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of TYK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620336(CHEMBL5423566)
Affinity DataIC50: 257nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620336(CHEMBL5423566)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK1 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620336(CHEMBL5423566)
Affinity DataIC50: 2nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed