BDBM50620334 CHEMBL5438892

SMILES Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn(CCC#N)c1

InChI Key InChIKey=VYUZMRQDNWEZOD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50620334   

TargetTyrosine-protein kinase JAK3(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620334(CHEMBL5438892)
Affinity DataIC50: 55nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620334(CHEMBL5438892)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of TYK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620334(CHEMBL5438892)
Affinity DataIC50: 228nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620334(CHEMBL5438892)
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK1 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620334(CHEMBL5438892)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed