BDBM50620050 CHEMBL5425498

SMILES C[C@@H]1COCCN1c1nc(nc2c1CN(C(=O)c1ccc3OCOc3c1)C2(C)C)-c1cccc2[nH]ccc12

InChI Key InChIKey=MFZAHAAVYSHLCP-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50620050   

TargetSerine/threonine-protein kinase ATR(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 5nMAssay Description:Inhibition of ATR (unknown origin) using peptide as substrate preincubated for 10 mins followed by substrate addition by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 33nMAssay Description:Inhibition of mTOR (unknown origin) using peptide as substrate preincubated for 10 mins followed by substrate addition by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using alpha-naphthoflavone as substrate preincubated for 5 mins followed by NADPH addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using sulfaphenazole as substrate preincubated for 5 mins followed by NADPH addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using nootkatone as substrate preincubated for 5 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using quinidine as substrate preincubated for 5 mins followed by NADPH addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate preincubated for 5 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using peptide as substrate preincubated for 10 mins followed by substrate addition by microplate reader anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 516nMAssay Description:Inhibition of ATM (unknown origin) using peptide as substrate preincubated for 10 mins followed by substrate addition by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620050(CHEMBL5425498)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DNA-PK (unknown origin) using peptide as substrate preincubated for 10 mins followed by substrate addition by microplate reader analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed