BDBM50619108 CHEMBL5408994
SMILES CC(C)n1cc(cn1)-c1nc(Nc2ccc(CNC(=O)C3CC3)cc2)ncc1C
InChI Key InChIKey=BGXJJFPQOWNIAF-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50619108
TargetTyrosine-protein kinase JAK2(Human)
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 205nMAssay Description:Inhibition of JAK2 V617F mutant in human SET2 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Mouse)
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cellsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of FLT3 in human MOLM-13 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Human)
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Human)
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Human)
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 156nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of TYK2 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
The Affiliated Hospital of Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 311nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair