BDBM50618977 CHEMBL5396156

SMILES Cc1cc(Nc2ncc3ccc(cc3n2)-c2cnc3OCCNc3c2C)ccc1NC(=O)CN1CCC1

InChI Key InChIKey=LNCDWMAESXCRDI-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50618977   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50618977(CHEMBL5396156)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50618977(CHEMBL5396156)
Affinity DataIC50: 3nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation at Ser376 residue preincubated for 60 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50618977(CHEMBL5396156)
Affinity DataEC50:  1.5nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Mus musculus)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50618977(CHEMBL5396156)
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse HPK1 in mouse EL4 cells assessed as increase in IL-2 release preincubated for 60 mins followed by alphaCD3/alphaCD28 DynabeadsTM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed