BDBM50618967 CHEMBL5409078

SMILES Cc1c2NCCOc2ncc1-c1ccc2cnc(Nc3ccc4COCc4c3)nc2c1

InChI Key InChIKey=OGBMVXIMELSEES-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50618967   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50618967(CHEMBL5409078)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50618967(CHEMBL5409078)
Affinity DataIC50: 30nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation at Ser376 residue preincubated for 60 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50618967(CHEMBL5409078)
Affinity DataEC50:  165nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed