BDBM50618483 CHEMBL5419358

SMILES COc1cc2CCN(C)Cc2cc1Nc1nc(Nc2ccccc2S(=O)(=O)N(C)C)c2c(c[nH]c2n1)-c1cccnc1

InChI Key InChIKey=UVFANRIFEXGNPK-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50618483   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human HPK1 using myelin basic protein and [gamma33P]ATP as substrate incubated for 40 mins in presence of Mg/ATP by radiometric scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetLymphocyte cytosolic protein 2(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 1.04E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of human HPK1 in anti-human CD3 stimulated human Jurkat T cells assessed as inhibition of SLP76 phosphorylation preincubated for 10 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataEC50:  1.19E+3nMAssay Description:Inhibition of human HPK1 in human Jurkat T cells assessed as increase in anti-human CD3 stimulated IL-2 secretion preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed