BDBM50618119 CHEMBL5438736

SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)F)c1c(F)cc(cc1F)N1CCC2(CCN(CC2)C(=O)CN2Cc3cc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c4cc3C2)CC1

InChI Key InChIKey=RASJDLFEGKXLIV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50618119   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG in human HEK293 cells incubated for 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 5 mins in presence substrate followed by NADPH addition and measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes preincubated for 5 mins in presence substrate followed by NADPH addition and measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 5 mins in presence substrate followed by NADPH addition and measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 5 mins in presence substrate followed by NADPH addition and measured after 10 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 5 mins in presence substrate followed by NADPH addition and measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition and measured after 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed