BDBM50617916 CHEMBL5403690

SMILES CC(C)(O)CC(=O)N1CCc2cc(Nc3ncc(c(N[C@@H]4CC[C@H](N)CC4)n3)C(F)(F)F)ccc2C1

InChI Key InChIKey=LHDKPFSHXFFALR-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50617916   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type FLT3 (unknown origin) using peptide substrate TK-S and ATP as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) using peptide substrate TK-S and ATP as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of CHK1 (unknown origin) using peptide substrate S1 and ATP as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of c-KIT (unknown origin) using peptide substrate TK-S and ATP as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 10nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 18nMAssay Description:Inhibition of AMPK alpha2beta1gamma1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 64nMAssay Description:Inhibition of TAK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 92nMAssay Description:Inhibition of P70S6K (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MET (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCasein kinase I isoform alpha(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CK1 alpha (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50617916(CHEMBL5403690)
Affinity DataIC50: 5.84E+4nMAssay Description:Inhibition of hERG expressed in HEK293 cells assessed as inhibition of channel current amplitude by whole cell patch clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed