BDBM50617567 CHEMBL5395794

SMILES C[C@H]1CCCN1Cc1cc2cnc(NC(=O)c3ccc4n(C)ncc4c3)cc2[nH]1

InChI Key InChIKey=QRYISIPABXJVOQ-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50617567   

TargetProtein ENL(Human)
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50617567(CHEMBL5395794)
Affinity DataIC50: 50nMAssay Description:Inhibition of 3xFLAG-HA-tagged wild-type human ENL YEATS domain using biotinylated peptide as substrate preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein ENL(Human)
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50617567(CHEMBL5395794)
Affinity DataKd:  119nMAssay Description:Binding affinity to 3xFLAG-HA-tagged wild-type human ENL YEATS domain assessed as dissociation constant by ITC titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein ENL(Human)
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50617567(CHEMBL5395794)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5x6His-tagged ENL YEATS domain (unknown origin) using biotinylated peptide H3K9cr (1 to 20 residues) preincubated for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein ENL(Human)
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50617567(CHEMBL5395794)
Affinity DataKd:  120nMAssay Description:Binding affinity to ENL YEATS domain (unknown origin) at 100 uM by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed