BDBM50617125 CHEMBL5398852

SMILES C[C@H]1CN(C[C@H]1Nc1nccc(n1)-c1c(nn2ccccc12)-c1ccccc1)C(=O)c1ccc(NC(=O)\C=C\CN(C)C)cc1

InChI Key InChIKey=FVONQZQMUHLATI-UHFFFAOYSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50617125   

TargetMitogen-activated protein kinase 8(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617125(CHEMBL5398852)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of His-tagged human recombinant JNK1 expressed in insect cells incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617125(CHEMBL5398852)
Affinity DataIC50: 70nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617125(CHEMBL5398852)
Affinity DataIC50: 84nMAssay Description:Inhibition of GST-tagged human recombinant JNK3 expressed in insect cells incubated for 1 hr in presence of ATP by Z'-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617125(CHEMBL5398852)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to wild type partial length human PIKFYVE (F1512 to C2098 residues) expressed in mammalian expression system by KdELECT kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617125(CHEMBL5398852)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Nano-Luc fused PIKFYVE (unknown origin) expressed in HEK293T cells pretreated for 3 hrs followed by K8-tarcer addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617125(CHEMBL5398852)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Nano-Luc fused JNK1 (unknown origin) expressed in HEK293T cells pretreated for 3 hrs followed by K5-tarcer addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617125(CHEMBL5398852)
Affinity DataIC50: 132nMAssay Description:Inhibition of Nano-Luc fused JNK2 (unknown origin) expressed in HEK293T cells pretreated for 3 hrs followed by K5-tarcer addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617125(CHEMBL5398852)
Affinity DataIC50: 15nMAssay Description:Inhibition of GST-tagged human recombinant p38alpha expressed in Escherichia coli by Lanthascreen Binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed