BDBM50616937 CHEMBL5404269

SMILES CNC(=O)[C@@H]1CC[C@H](C1)n1c(nc2ccc(cc12)C(=O)NCc1cccc(c1)C(N)=O)-c1ccc2cnccc2c1

InChI Key InChIKey=UOCCUBNXBUXTNS-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50616937   

TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta by LanthaScreen TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 2.67E+5nMAssay Description:Inhibition of ACVRL1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of ACVR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BMPR1A (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of TGFBR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BMPR1B (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataKi:  6.20nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed