BDBM50616733 CHEMBL5422549

SMILES CC#CC(=O)NC12CC(C1)(C2)NC1=C(Cl)C(=O)c2ncccc2C1=O

InChI Key InChIKey=XLARJZRINWFNRT-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50616733   

TargetHistone-lysine N-methyltransferase NSD2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50616733(CHEMBL5422549)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant human NSD2 (941 to 1240 residues) using SAM as substrate incubated for 3 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50616733(CHEMBL5422549)
Affinity DataIC50: 690nMAssay Description:Inhibition of NSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50616733(CHEMBL5422549)
Affinity DataIC50: 750nMAssay Description:Inhibition of NSD3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50616733(CHEMBL5422549)
Affinity DataIC50: 250nMAssay Description:Inhibition of EZH2 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition and measured after 4 hrs by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50616733(CHEMBL5422549)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50616733(CHEMBL5422549)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT4 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50616733(CHEMBL5422549)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT5 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50616733(CHEMBL5422549)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MLL1 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition and measured after 4 hrs by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2D(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50616733(CHEMBL5422549)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MLL2 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition and measured after 4 hrs by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed