BDBM50615478 CHEMBL5280385

SMILES CCOc1ccc(cc1)-n1cc(C#N)c2ncnc(N3CCN(Cc4ccccc4)CC3)c12

InChI Key InChIKey=OGPQJQXTBPOZLW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50615478   

TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50615478(CHEMBL5280385)
Affinity DataIC50: 7.29E+3nMAssay Description:Inhibition of P-gp (unknown origin) incubated for 30 mins by calcein AM analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50615478(CHEMBL5280385)
Affinity DataIC50: 859nMAssay Description:Inhibition of MRP1 in human NCI-H69AR cells incubated for 180 mins in presence of daunorubicin by flow cytometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed