BDBM50614177 CHEMBL5287545

SMILES COc1cc(cc(c1)OC)C#Cc2c3c(ncnc3n(n2)[C@@H]4CCN(C4)C(=O)C=C)N

InChI Key InChIKey=KEIPNCCJPRMIAX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50614177   

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50614177(CHEMBL5287545)
Affinity DataIC50: 29nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50614177(CHEMBL5287545)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of N-terminal GST tagged recombinant human VEGFR2 (aa805 to 1356 residues) expressed in baculovirus expression system using Poly- (Glu4:Ty...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50614177(CHEMBL5287545)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50614177(CHEMBL5287545)
Affinity DataIC50: 3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed