BDBM50614093 CHEMBL5273859

SMILES [H][C@]12CN(C[C@]([H])(C1)c1ccc(NC(=O)Nc3cccc(c3)C#N)c(=O)n1C2)C(=O)c1ccc2ccccc2c1

InChI Key InChIKey=GHTLFIBIXBWORE-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50614093   

TargetProteasome subunit beta type-5(Human)
Middlesex University

Curated by ChEMBL
LigandPNGBDBM50614093(CHEMBL5273859)
Affinity DataKi:  3.42E+3nMAssay Description:Competitive inhibition of human 20S constitutive proteosome beta5c subunit using Suc-LLVY-AMC as substrate measured after 10 mins by fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Middlesex University

Curated by ChEMBL
LigandPNGBDBM50614093(CHEMBL5273859)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of human 20S constitutive proteosome beta5c subunit using Suc-LLVY-AMC as substrate measured after 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Middlesex University

Curated by ChEMBL
LigandPNGBDBM50614093(CHEMBL5273859)
Affinity DataIC50: 2.21E+4nMAssay Description:Inhibition of human 20S immuno proteosome beta5i subunit using Suc-LLVY-AMC as substrate measured after 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed