BDBM50613914 CHEMBL5274746

SMILES Cc1cccc(n1)-c1[nH]c(NCc2ccc(F)c(F)c2)nc1-c1ccc2[nH]ncc2c1

InChI Key InChIKey=IHPNHLBHEBHRGJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50613914   

TargetTGF-beta receptor type-1(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50613914(CHEMBL5274746)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of ALK5 in human Hs-578T cells assessed as effect of TGF-beta-induced Smad3/4 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50613914(CHEMBL5274746)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50613914(CHEMBL5274746)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50613914(CHEMBL5274746)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50613914(CHEMBL5274746)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50613914(CHEMBL5274746)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed