BDBM50613198 CHEMBL5266785

SMILES COc1cc(cc(OC)c1Oc1ccccc1)-c1nn2C(CCNc2c1C(N)=O)C1CCN(CC1)C(=O)C=C

InChI Key InChIKey=HEFUQOMXBZIABJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50613198   

TargetTyrosine-protein kinase BTK(Human)
Beigene (Beijing) Co.

Curated by ChEMBL
LigandPNGBDBM50613198(CHEMBL5266785)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells using Biotin-AVLESEEELYSS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Beigene (Beijing) Co.

Curated by ChEMBL
LigandPNGBDBM50613198(CHEMBL5266785)
Affinity DataIC50: 4.71E+3nMAssay Description:Inhibition of EGFR (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Beigene (Beijing) Co.

Curated by ChEMBL
LigandPNGBDBM50613198(CHEMBL5266785)
Affinity DataIC50: 59nMAssay Description:Inhibition of TEC (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed