BDBM50613196 CHEMBL5276374
SMILES COc1cc(cc(OC)c1C)-c1nn2[C@@H](CCNc2c1C(N)=O)C1CCN(CC1)C(=O)C=C
InChI Key InChIKey=ZFDGMDVYMNWICG-UHFFFAOYSA-N
Data 24 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50613196
Affinity DataIC50: 99nMAssay Description:Inhibition of human TEC preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.58E+4nMAssay Description:Inhibition of CYP3A4 in pooled human liver microsomes using testosterone as substrate assessed as reduction in 6-OH-testosterone metabolite formation...More data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of CYP3A4 in pooled human liver microsomes using midazolam as substrate assessed as reduction in OH-midazolam metabolite formation by LC-M...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2D6 in pooled human liver microsomes using dextromethorphan as substrate assessed as reduction in dextrophan metabolite formation by...More data for this Ligand-Target Pair
Affinity DataIC50: 3.74E+4nMAssay Description:Inhibition of CYP2C9 in pooled human liver microsomes using diclofenac as substrate assessed as reduction in OH-diclofenac metabolite formation by LC...More data for this Ligand-Target Pair
Affinity DataIC50: 3.63E+4nMAssay Description:Inhibition of CYP2C8 in pooled human liver microsomes using amodiaquine as substrate assessed as reduction in N-desethylamodiaquine metabolite format...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2B6 in pooled human liver microsomes using bupropion as substrate assessed as reduction in OH-bupropion metabolite formation by LC-M...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP1A2 in pooled human liver microsomes using phenacetin as substrate assessed as reduction in acetaminophen metabolite formation by LC...More data for this Ligand-Target Pair
Affinity DataIC50: 223nMAssay Description:Inhibition of FLAG-tagged TEC autophosphorylation in HEK293 cells incubated for 2 hrs by MSD electrochemiluminescence immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR autophosphorylation at Tyr1068 residue in EGFR-amplified human A-431 cells preincubated with compound for 1 hrs followed by stimul...More data for this Ligand-Target Pair
Affinity DataIC50: 94nMAssay Description:Inhibition of human ERBB4 preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration b...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human BMX preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.15E+4nMAssay Description:Inhibition of CYP2C19 in pooled human liver microsomes using S-mephenytoin as substrate assessed as reduction in OH-S-mephenytoin metabolite formatio...More data for this Ligand-Target Pair
Affinity DataIC50: 185nMAssay Description:Inhibition of human JAK3 preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by...More data for this Ligand-Target Pair
Affinity DataIC50: 169nMAssay Description:Inhibition of human BLK preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by ...More data for this Ligand-Target Pair
Affinity DataIC50: 621nMAssay Description:Inhibition of human EGFR preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by...More data for this Ligand-Target Pair
Affinity DataIC50: 215nMAssay Description:Inhibition of human MYO3b preincubated with compound for 1 hrs followed by ATP/33P-ATP addition and measured after 2 hrs by radioactive filter-bindin...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of human NLK preincubated with compound for 1 hrs followed by ATP/33P-ATP addition and measured after 2 hrs by radioactive filter-binding ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human TXK preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human BTK preincubated with compound for 1 hrs followed by ATP/33P-ATP addition and measured after 2 hrs by radioactive filter-binding ...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of BTK phosphorylation at Tyr 223 residue in human Ramos cell incubated for 3 hrs by HTRF-based analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 99nMAssay Description:Inhibition of TEC (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concen...More data for this Ligand-Target Pair
Affinity DataIC50: 621nMAssay Description:Inhibition of EGFR (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km conce...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells using Biotin-AVLESEEELYSS...More data for this Ligand-Target Pair