BDBM50612971 CHEMBL5273043

SMILES CC(NC(=O)C1CCCC1)C(=O)Nc1nnc(Cc2ccc(cc2)[N+]([O-])=O)s1

InChI Key InChIKey=LSKCLOVTKNMGQQ-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50612971   

LigandPNGBDBM50612971(CHEMBL5273043)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of human full length USP21 using Btn-Ahx-PNIRFLD-K(Ubi)-LPQQT-GD-amide as substrate preincubated for 15 to 20 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50612971(CHEMBL5273043)
Affinity DataIC50: 2.25E+4nMAssay Description:Inhibition of human USP21 using ubiquitin rhodamine 110 110 as substrate preincubated for 15 to 20 mins followed by enzyme addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50612971(CHEMBL5273043)
Affinity DataIC50: 2.25E+4nMAssay Description:Inhibition of human USP21 using ubiquitin aminoluciferin as substrate incubated for 25 mins by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50612971(CHEMBL5273043)
Affinity DataKd:  7.90nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged USP21 (209 to 563 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissoci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50612971(CHEMBL5273043)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human His-tagged USP2 (259 to 605 residues) using ubiquitin rhodamine 110 110 as substrate preincubated for 15 to 20 mins followed by e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed