BDBM50612449 CHEMBL5271471

SMILES CCC(=O)CCCCC[C@H](NC(=O)C1CN(C)C1)c1ncc(o1)-c1cc2ccccc2nc1OC

InChI Key InChIKey=YOCBGMVQRJHNRU-UHFFFAOYSA-N

Data  11 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50612449   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataEC50:  50nMAssay Description:Inhibition of HDAC in human HeLa cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate incubated for 4 hrs by spectrophotometer based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human HDAC3 expressed in baculovirus infected insect cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 177nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of hERG potassium channel incubated for 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of hERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
IRBM Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed