BDBM50611444 CHEMBL5273123

SMILES Cc1cc(Cn2nc(Br)cc2Cl)cc(=O)n1C[C@H]1C[C@@H]1C#N

InChI Key InChIKey=SKDDVCIQXLNTPS-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50611444   

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50611444(CHEMBL5273123)
Affinity DataEC50:  900nMAssay Description:Positive allosteric modulator activity at GluN2A NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlutamate receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50611444(CHEMBL5273123)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of [3H]-HBT1 from His-tagged GluA2-AMPA receptor LBD (unknown origin) in presence of glutamate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50611444(CHEMBL5273123)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulator activity at GluN2B NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50611444(CHEMBL5273123)
Affinity DataEC50:  1.90E+3nMAssay Description:Positive allosteric modulator activity at GluN2C NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50611444(CHEMBL5273123)
Affinity DataEC50:  5.10E+3nMAssay Description:Positive allosteric modulator activity at GluN2D NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed