BDBM50610833 CHEMBL5276884

SMILES COc1ccc(c2ncccc12)S(=O)(=O)Nc1ccccc1C#Cc1cnc(C(O)=O)c(C)c1

InChI Key InChIKey=XBFZSSVCJZBCFQ-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50610833   

TargetMonocarboxylate transporter 4(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50610833(CHEMBL5276884)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human MCT4 in human MDA-MB-231 cells assessed as inhibition of lactate efflux preincubated for 30 mins followed by D(+)glucose and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50610833(CHEMBL5276884)
Affinity DataIC50: 99nMAssay Description:Binding affinity to full-length C-terminal GFP-tagged human MCT4 incubated for 1 hrs by fluorescence cross-correlation spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50610833(CHEMBL5276884)
Affinity DataIC50: 137nMAssay Description:Inhibition of human MCT4 in human NCI-H358 cells assessed as inhibition of lactate efflux preincubated for 30 mins followed by D(+)glucose and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50610833(CHEMBL5276884)
Affinity DataIC50: 239nMAssay Description:Inhibition of human MCT4 in human NCI-H441 cells assessed as inhibition of lactate efflux preincubated for 30 mins followed by D(+)glucose and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50610833(CHEMBL5276884)
Affinity DataKi:  11nMAssay Description:Binding affinity to full-length C-terminal GFP-tagged human MCT4 incubated for 1 hrs by fluorescence cross-correlation spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed