BDBM50610334 CHEMBL5174597

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(F)=C)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1

InChI Key InChIKey=ZCGQZLKPUVGCBQ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50610334   

TargetGTPase KRas(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50610334(CHEMBL5174597)
Affinity DataEC50:  320nMAssay Description:Induction of KRAS G12C degradation in human MIA PaCa-2 cells assessed as reduction in KRAS G12C protein level incubated for 24 hrs by immunoblotting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed